Sanval (ZOLPIDEM 10 mg) 20 Film Coated Tablets in Box

0 from 5 / 0 Vote
Добави мнение

24.89 USD 27.00 USD You save 2.11 USD

Indications of Sanval®
Sleep disturbances: difficulty falling asleep, early and nocturnal awakenings. Active substance:
zolpidem tartrate - By Lek - Macedonia

-------------------------------------------------- ----------------------------------
Pharmacodynamics
Zolpidem is a hypnotic that belongs to the group of imidazopyridines. Differing in structure from benzodiazepines, zolpidem has a sedative effect, while the anxiolytic, anticonvulsant and central muscle relaxant effect is expressed slightly.

According to the classification, the allosteric sites of the GABA complex that benzodiazepines bind to are called omega-modulating sites or receptors. To date, three subtypes have been identified: 1, 2 and 3. Unlike benzodiazepines, which non-selectively bind and activate all three subtypes of omega receptors, zolpidem binds selectively to the omega1 receptor, therefore the sedative effect of the drug is observed at lower doses than doses necessary for the development of muscle relaxant, anticonvulsant and anxiolytic effect.

Omega1 receptors are mainly located in the fourth layer of the sensory cortex of the cerebral hemispheres, in the cerebellum, pons, and lower tubercles of the quadrocholium.

Zolpidem showed low affinity for omega2 receptors (lumbar spine, hippocampus) and omega3 receptors (certain peripheral areas). Modern experience shows that the pharmacological action of zolpidem is different from that of benzodiazepines.

Interaction with omega receptors leads to the discovery of neuronal ionophore channels for chlorine ions.

The effect comes quickly. It shortens the time of falling asleep, reduces the number of nighttime awakenings, increases the total duration of sleep and improves its quality. Extends stage II of sleep and stage of deep sleep (III and IV).
Pharmacokinetics
Zolpidem is rapidly absorbed from the gastrointestinal tract. After receiving a dose of 5 and 10 mg Cmax in plasma is 59 and 121 ng / ml, respectively, Tmax - from 0.5 to 3 hours (average Tmax - 1.6 hours).

With food in the stomach, zolpidem absorption slows down a little. To speed up the onset of sleep, zolpidem should not be taken with food or immediately after a meal. The pharmacokinetics of zolpidem remain unchanged for several weeks.

Bioavailability of zolpidem reaches 70%, connection with plasma proteins - 92%.

There is a linear relationship between the dose of the drug and the concentration of zolidem in plasma.

It is metabolized in the liver to form three inactive metabolites, which are excreted by the kidneys (about 60%) and through the intestines (about 40%).

Оставете вашето мнение


Невалидно

Невалиден